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 Powder Airborne Evaluation

Proposing Optimized Chemical Hazard Control Facilities by Predicting Airborne of API(Active Pharmaceutical Ingredient) Powder

JGC has confirmed that the level of powder available in air in the work environment bears a proportional relationship to the containment performance of the equipment, the intensity of the work, and the airborne properties of the powder itself. JGC has developed a new technology to predict the airborne properties of powder based on molecular properties, and has defined a “Airborne index” for the predicted values.

Below, we detail an example of an actual survey.

Relationship between powder dispersion index and level of Dispersion in a given work environment (example survey)

Conventionally, during containment testing carried out after hand-over of the site, substitute powders such as lactose are used for testing as long as possible, but by using the powder airborne index to calculate the values for the actual feed powder used at the plant, it is possible extrapolate the results of the containment testing using substitute powder to the actual feed powder, and evaluate the effectiveness of containment on a fixed scale. The airborne index of a given powder can be calculated based on a sample as small as one gram.

In order to calculate the airborne index for highly active molecules, JGC installed a dedicated facility at our technology research center, where we are able to calculate the airborne index for highly active molecules at the request of our clients. JGC holds the patent for this technology. In addition, JGC is able to use this dispersion data to propose chemical hazard control facilities that are optimized to prevent excess.

Dispersion measuring equipment

Airborne measuring equipment

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